Nayak, A. et al. (2011). Neurology Research International, Article ID 563784, 7 pages, doi:10.1155/2011/563784.

Huntington's Disease: An Immune Perspective

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Annapurna Nayak, 1, 2 Rafia Ansar, 1 Sunil K. Verma, 3 Domenico Marco Bonifati, 4 and Uday Kishore 1 ,*

1Centre for Infection, Immunity and Disease Mechanisms, Biosciences School of Health Sciences and Social Care, Brunel University, West London UB8 3PH, UK
2Centre of Biotechnology and Bioinformatics, School of Life Sciences, Jawaharlal Nehru Institute for Advanced Study, Secunderabad, Andhra Pradesh, India
3Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
4Unit of Neurology, Department of Neurological Disorders, Santa Chiara Hospital, Largo Medaglie d’oro 1, 38100 Trento, Italy
*Uday Kishore: ku.ca.lenurb@erohsik.yadu
Academic Editor: Mohammed Rachidi
Received November 17, 2010; Revised March 31, 2011; Accepted May 12, 2011.

Abstract

Huntington’s disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

Abbreviations

HD: Huntington’s disease; APC: antigen presenting cells; Aβ: amyloid β (1–42) peptide; AD: Alzheimer’s disease; TNF: tumour necrosis factor; DC: dendritic cells; immDC: immature dendritic cells; MHC: major histocompatibility complex CNS: central nervous system; Htt: Huntingtin; MSN: medium spiny neurons; MCP: monocyte chemotactic protein; DAF: decay accelerating factor; CSF: Cerebrospinal fluid.


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Annapurna Nayak, Rafia Ansar, Sunil K. Verma, Domenico Marco Bonifati, and Uday Kishore, “Huntington's Disease: An Immune Perspective,” Neurology Research International, vol. 2011, Article ID 563784, 7 pages, 2011. doi:10.1155/2011/563784

Short Citation Nayak, A. et al. (2011). Neurology Research International, Article ID 563784, 7 pages, doi:10.1155/2011/563784.
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