Verma, S. K. et al. (2011). Protein Cell, 2, 237-249.

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.

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Department of Medical Oncology, Medical Sciences Division, The University of Oxford, Oxford OX3 9DU, United Kingdom
Ovarian Cancer Group, CRUK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
Protein Phosphorylation Laboratory, London Research Institute, CRUK Lincoln’s Inn Fields Laboratories, 44 Lincoln’s Inn Fields, London WC2A 3PX, United Kingdom
Kings College London, The Division of Cancer Studies, Section of Cancer Cell Biology and Imaging, New Hunt’s House, Guy’s Hospital, 2nd Floor, St Thomas Street, London SE1 1UL, United Kingdom
Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
Cancer Institute and Institute of Molecular Medicine, Amrita Institute of Medical Sciences, Elamakkara P.O., Kochi, Kerala 682 026, India
Center for Infection, Immunity and Disease Mechanisms, Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge UB8 3PH, West London, United Kingdom

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

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Keywords

Microtubule; Protein-protein interaction; Rap1A; RASSF1A; Vimentin

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The tumour suppressor RASSF1A is a novel effector of small G protein Rap1A

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DOI 10.1007/s13238-011-1028-z

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Verma, S. K., Ganesan, T. S., Kishore, U., Parker, P. J. (2011). The tumour suppressor RASSF1A is a novel effector of small G protein Rap1A. Protein Cell, 2, 237-249.

Short Citation Verma, S. K. et al. (2011). Protein Cell, 2, 237-249.
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